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Despite the researchers acknowledging that "concerns had previously been raised about possible detrimental effects of the administration pimobendan to dogs with preclinical MMVD", they did not bother to report measurements of the contractility and/or fractional shortening of the dogs' hearts during the treatment period

A thiamine deficiency diagnosis is determined by laboratory tests, not by clinical signs or symptoms of the disease

Imbalances of iron homeostasis may induce cell death of normal but also of malignant cells

All experiments involving animal use were performed in accordance with the ARRIVE guidelines

and International Publication Nos

Mitochria produce ROS during energy generation but excess ROS directly damages mitochondrial DNA and disrupts energy production systems