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However, moderate oxidative stress activates another nuclear transcriptional factor, nuclear factor-erythroid 2-related factor 2 (Nrf2)

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Nature 227 : 680685 Ho YS, Dey MS, Crapo JD 1996 Antioxidant enzyme expression in rat lungs during hyperoxia

Mechanistically, Ipamorelin operates through the ghrelin receptor (GHS-R1a), coupling to Gq-mediated calcium mobilization and PKC activationa signaling pathway complementary to GHRH's cAMP-PKA mechanism