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14 The classic appearance of a BCC is a rodent ulcer, which is a lesion with raised pearly edges and central atrophy or ulceration (Figure 5)

The MITF (microphthalmia-associated transcription factor) pathway is simultaneously upregulated downstream of PKA/CREB activation, serving as the master transcriptional regulator that coordinates the entire melanogenic enzyme cascade, and this cAMP-PKA-CREB-MITF axis represents the canonical signaling pathway measured in Melanotan II potency assays

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The efficacy of chemoradiotherapy for this disease is uncertain, but there is some literature suggesting that stereotactic radiotherapy can be used to treat this disease, but more evidence-based evidence is lacking [8, 9]