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This evaluation was conducted using a holistic approach to establish a scientific basis for the review

They reported that p53 suppresses accumulation of cytoplasmic chromatin fragments (CCF), including DNA damage signaling marker H2A.X, and its downstream inflammatory phenotype (e.g., SASP) of monocytes and macrophages in liver

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All procedures were approved and conducted per the University Committee on Animal Resources at the University of Rochester Medical Center (UCAR #2010-024E, UCAR-2008-016E)

This change leaded to the collapse of the sinus wall, which caused red blood cells to infiltrate the Disse space

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