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Elderly, Cachectic, or Debilitated Patients: Life-threatening respiratory depression is more likely to occur in elderly, cachectic, or debilitated patients because they may have altered pharmacokinetics or altered clearance compared to younger, healthier patients (see WARNINGS, Life-Threatening Respiratory Depression)

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Lancet 392, 22992312

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J Nutr Biochem 25:456462 [DOI] [PubMed] [Google Scholar] Polat N, Ciftci O, Cetin A, Ylmaz T (2016) Toxic effects of systemic cisplatin on rat eyes and the protective effect of hesperidin against this toxicity

After caring for patients with life-threatening conditions in advanced stages of decline, she resolved to find ways to help prevent patients from winding up in the ICU in the first place