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ROM and REW contributed equally and share last authorship

According to the Centers for Disease Control (CDC), an estimated 8,000 to 18,000 people are hospitalized with Legionnaires disease each year in the U.S

In fact, besides their efficacy, the safety profile of the combined use of fenofibrate with statins is comparable to that of statin monotherapy [26]

Although anti-cancer therapy targeting metabolism has achieved some gratifying results, it is still currently believed that this field has the following shortcomings for possible future breakthroughs: 1) The side effects of such drugs limit their clinical effects as the optimal dose window is hard to be determined