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Nsairat H, Mahmoud IS, Odeh F, Abuarqoub D, Al-Azzawi H, Zaza R, et al

The NF-B pathway regulates various factors upstream and downstream, further mediating the inflammatory response, oxidative stress response, liver fibrosis, cell apoptosis, autophagy and pyroptosis of liver tissue to promote the process of MASLD (384)

Persistently high levels of ROS lead to oxidative stress, cellular damage, dysfunction, and even cell death [181]

This is also consistent with persister cell formation under other stress conditions ( Um et al

Guo J, et al

10.1038/s41392-020-0168-0 75 LeidnerR.Sanjuan SilvaN.HuangH.SprottD.ZhengC.ShihY