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Hesperidin (Matias et al., 2017), rutin (El-Sayed el et al., 2008), and rhamno (Omar et al., 2017) can reduce the amount of free Ca 2+ located between brain cells when fighting against neurogenic excitotoxicity and can attenuate the decrease of the mitochondrial membrane potential and increase caspase-3 activity (Lutz et al., 2015)

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John MV, Schneeweiss-Gleixner M, Eisenwort G, Peter B, Berger D, Stefanzl G, Konopleva M, Andreeff M , Isalm W, Schwaab J, Reiter A, Sperr WR, Arock M, Valent P, Gleixner K

In addition, in restoring intestinal mechanical barrier function, PNS can alleviate intestinal mucosal barrier damage by increasing the expression of ZO-1, claudin-1, and occludin in colonic mucosal tissue (Lu et al., 2020)

Pagnussat GC, Yu HJ, Ngo QA, Rajani S, Mayalagu S, Johnson CS, Capron A, Xie LF, Ye D, Sundaresan V (2005) Genetic and molecular identification of genes required for female gametophyte development and function in Arabidopsis

7A) and significantly reduced the wound width in scratch assays under LPS challenge (Fig