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Elevated Growth/differentiation factor 15 (GDF15) level in serum and increased GDF15 expression in cancer tissues are reported in patients with various cancers, and associated with the poor prognosis of the patients (Welsh et al., 2001

Anthracycline-based regimens have proven to be one of the most effective treatments in this setting

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Conversely, if GSSG oxidizes PDI, then the net result would be an increase in the concentration of GSH relative to GSSG

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