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doi: 10.1016/j.brainresbull.2005.07.011 2 CampbellDBBuieTMWinterHBaumanMSutcliffeJSPerrinJMet al

Liu, Sensors 20 , 6925 (2020) N

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Although genetic methods (i.e., gene knockout and knockdown) are powerful approaches, they often activate compensatory pathways, making it difficult to determine the specific role of each enzyme (Zainol et al., 2023)

Conclusions In summary, our results show that the use of COCs containing EE and DRSP causes shifts in endogenous estrogen biotransformation that result in a relative increase in the rate of estrogen conjugation, hydroxylation, and methylation, especially for E1