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2 Mitochondrial dysfunctions in kidney diseases 2.1 Mitochondrial homeostasis imbalance Mitochondrial quality control (MQC) is an elaborate mechanism to maintain homeostasis, ensuring the enough numbers of functional mitochondria (Pickles et al., 2018

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It reduces angiotensin II levels by inhibiting angiotensin-converting enzyme activity, thereby mitigating inflammation, oxidative stress, and MMP-13 expression while upregulating the anti-inflammatory cytokine IL-10 (68)

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