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Our own studies indicate that therapeutic intervention with NK-1R antagonists can limit neuroinflammation, reactive gliosis and demyelination in a mouse model of streptococcal meningitis (Chauhan et al., 2011) while other groups have shown efficacy of these agents in animal models of MS (Nessler et al., 2006

doi: 10.1016/j.tips.2022.04.003 107 FuJWuH

Results The p53 TAD2 region plays a crucial role in the interaction with FOXO4 FHD Interactions between FOXO4 and p53 in the nucleus have been reported to promote cellular senescence 34

However, in addition to the alpha chain, the IL-2 receptor contains also a beta and gamma chain and, in its trimeric form, is expressed transiently on activated T lymphocytes and constitutively on regulatory T cells

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