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doi: 10.1007/s12602-022-09909-5, 10

Hormones An unbalance of female hormones caused by periods, period irregularity, pregnancy, menopause, birth control pills can cause pigmentation

It is important to note that whilst the injection itself may maintain adequate B12 levels for weeks to months, the clinical benefits such as improved energy, cognitive function, and resolution of neurological symptomsdepend on consistent maintenance of optimal levels

In contrast to phytoestrogens such as soy isoflavones, black cohosh does not seem to produce estrogenic type stimulation of breast or uterine tissues and its effects may be mediated by serotonergic and dopaminergic pathways, antioxidant sources, or anti-inflammatory actions (98)

The absence of large-scale human trials makes the true frequency of allergic responses across broader populations unknown

In addition to hallmark motor symptoms, it manifests a wide range of nonmotor complications, including cognitive decline, neuropsychiatric symptoms, autonomic dysfunction, and comorbid metabolic and infectious diseases