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This occurs because the senescence of hepatic stellate cells, which are partly responsible for forming fibrotic scar tissue, acts as a natural mechanism that delays and limits fibrotic changes in response to injury [142, 143]

Several transition metal-transporting genes including SLC11A2 (DMT1), TFR2 , SLC25A37 , STEAP1 , MMGT1 and PRNP were identified as robust targets for reduction of Cu toxicity (Fig

10.1038/srep12936 225 ZhouF.ZhuZ.GaoJ.YangC.WenL.LiuL.et al (2018)

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Biomimetic matrix stiffness modulates hepatocellular carcinoma Malignant phenotypes and macrophage polarization through multiple modes of mechanical feedbacks