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Therapies that modulate autophagy like rapamycin (which induces autophagy via mTOR inhibition) have shown in rodents to mitigate postoperative cognitive dysfunction by promoting clearance of damaged mitochondria in the brain (77)

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the role of supra-normal vitamin E doses, however, remains to be explored ( -thalassemia and SCD patients provided prove for its capacity to replenish the amount of GSH and, accordingly, reduce levels of oxidative stress ( Statements Data availability statement The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author