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FIGURE 4 8.1 Iron metabolism dysregulation Iron is unevenly distributed in the cerebral cortex: the metal burden in motor-related nucleiincluding the basal ganglia, amygdala, substantia nigra, hippocampus, and red nucleusis significantly higher than in other neural regions (Bartzokis et al., 2007)

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The data indicated that ES-induced cell death did not involve either the cleavage or activation of caspase 3 activity, known as a hallmark of apoptosis

Subsequently, DHICA undergoes conversion into the corresponding quinone species 53

Ueland PM, Mansoor MA, Guttormsen AB, Mller F, Aukrust P, Refsum H, and Svardal AM (1996)

2020;142:e214-33