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At the cellular level, this peptide acts as a signaling molecule that modulates gene expression across numerous pathways relevant to skin aging and repair

The B vitamins are necessary for red blood cell production, energy production from food, and nerve health

doi: 10.1093/carcin/14.2.183

coli : Escherichia coli eIF2: Eukaryotic initiation factor 2 alpha GDH: Glutamate dehydrogenase GLS: Glutaminase GLS1: Kidney-type glutaminase HCC: Hepatocellular carcinoma Hsp60: Heat shock protein 60 IDH: Isocitrate dehydrogenase MSC: Mesenchymal stromal cells mTORC1: Mammalian target of rapamycin complex 1 NO: Nitric oxide NOD-SCID mouse: Non-obsese diabetes severe combined immune-deficiency mouse NOS: Nitric oxide synthases NOS: Nitroc oxide synthase ODC: Ornithine decarboxylase OTC: Ornithine transcarbamylase pegylated arginase I: Peg-arg I PI3K-Akt Pathway: Phosphatidylinositol 3-kinase-protein kinase B pathway s.c.: Sub-cutaneous injection SLC1A5/38A2: Solute carrier family 1 member 5/38A2 T- ALL: T-lineage acute lymphoblastic leukemia TCA cycle: Tricarboxylic acid cycle TORC1: Target of rapamycin complex 1 TORC2: Target of rapamycin complex 2 -FBP: (R)-gamma-(2-fluoro-benzyl)-L-proline References Hanahan D, Weinberg RA

The increased glutathione redox status could be a compensatory mechanism in response to the increased oxidative burden due to anemia and obesity

Huo J, Yu M, Feng N, Zheng D, Zhang R, Xue Y, Khan A, Zhou H, Mei W, Du X, Shen X, Zhao L, Meng F