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Research has confirmed that the COVID-19 mortality rate sharply increases among seniors, with the majority of deaths reported among those aged 70 years and older 3 , and among individuals who have pre-existing conditions such as frailty, obesity, diabetes and hypertension independent of age 3

When cells are damaged or stimulated, HMGB1 is released from the nucleus into the extracellular space and participates in the pathological process of sepsis as a late inflammatory mediator (155)

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