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In some instances, its use in dogs is off-label (extra-label), which means that it is used outside the scope of the original product label, but based on clinical evidence and veterinary professional judgment

Contraindications and Precautions Thiazolidinediones are contraindicated in patients with (8): Heart failure Moderate to severe hepatic impairment Active or history of bladder cancer Pregnancy High-risk fracture Cytochrome CYP 2C8 and CYP 3A4 Adverse Effects and Black Box Warnings Thiazolidinediones have several adverse effects, including (8): Edema Congestive heart failure Weight gain Decreased bone density, leading to fractures Bladder cancer Hepatotoxicity Diabetic macular edema Increased ovulation and teratogenic effects Thiazolidinediones have a black box warning of congestive heart failure and myocardial ischemia

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