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rTFE3-L, rTFE3-S, and rTFE3-L-M106A remained retained in the cytosol under control conditions, while rapidly moving to the nucleus following starvation (Fig

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The Allosteric Discovery: A New Binding Paradigm Chugai Pharmaceutical's discovery program challenged this consensus by shifting the focus from the orthosteric binding site (the pocket occupied by endogenous GLP-1 and peptide agonists) to potential allosteric sites within the GLP-1 receptor's TMD