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doi: 10.1016/j.jinorgbio.2009.11.005 132 ChenYLuoXYinYThomasERLiuKWangWet al

Sodium bicarbonate for the treatment of severe metabolic acidosis with acute kidney injury

The BCL-2/MCL-1 balance in the apoptotic pathway is disrupted in drug-resistant clones, and BH3 mimics can alter mitochondrial apoptotic thresholds, thereby overcoming anti-apoptotic defenses