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Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc-, leading to glutathione depletion

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doi: 10.1016/J.IT.2022.02.008 201 TranVTPerrodeauESaldanhaJPaneIRavaudP

Isoproterenol hydrochloride (Sigma-Aldrich) was dissolved in PBS and added in culture medium at a final concentration of 10 M and maintained throughout the experiment

Cytochrome p450 oxidoreductase (POR) affects iron metabolism by removing hydrogen from polyunsaturated fatty acids, or by reducing Fe 3+ to Fe 2+ for electron transfer, to accelerate the circulation between Fe 3+ and Fe 2+ to promote ferroptosis (Zou et al., 2021)