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GSH is a tripeptide antioxidant present in all cells that maintains cellular redox homeostasis, with mitochondrial GSH (mGSH) playing a unique role in protecting mitochondrial DNA and respiratory chain proteins from oxidative damage ( via the glutamate-cystine antiporter (GC1), forming a relatively independent pool that accounts for 1015% of total cellular GSH but is critical for mitochondrial redox defense (Xu T

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