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Capecitabine and temozolomide versus FOLFIRI in RAS-mutated, MGMT-methylated metastatic colorectal cancer

To show the enzymatic region that binds substrates (H-site of GSTP1), we have included the structure of the anticancer drug chlorambucil reproducing the same binding position as in its co-crystal with GSTP1 (PDB structure 21GS)

Radiologic evaluation was based on modified Response Evaluation Criteria in Solid Tumors (mRECIST)

N-acetylcysteine (NAC) not only produces the antioxidant glutathione, but is also a glutaminergic receptor agonist 61

It is important to note that the absence of citation of specific studies of OS in these models of AD does not imply anything with respect to the significance of those studies

Trends in cancer