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A single molecular entity simultaneously activates both the GLP-1 receptor and the amylin receptor (calcitonin receptor complex), combining two complementary satiety and metabolic pathways: GLP-1 receptor activation : Glucose-dependent insulin secretion, glucagon suppression, delayed gastric emptying, and central appetite reduction through hypothalamic signaling Amylin receptor activation : Additional satiety signaling through the area postrema, complementary gastric emptying delay, and glucagon suppression through a distinct mechanism The unimolecular design means both receptor activations occur at a fixed ratio determined by the molecular structure

Frontiers in Aging Neuroscience Research by Soghra Bagheri et al., published in Frontiers in Aging Neuroscience

Association between glutathione S-transferases gene variants and COVID-19 severity in previously vaccinated and unvaccinated polish patients with confirmed SARS-CoV-2 infection

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Decreased vitamin C levels are known to support the pathophysiology of various diseases, such as cancer, endocrinopathies, and neurological disorders [52]

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