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In addition, inhibiting METTL17 significantly reduces mitochondrial RNA methylation, impairing the translation of mitochondrial protein-coding genes, affecting mitochondrial energy metabolism, and enhancing mitochondrial and intracellular ROS and lipid peroxidation levels

Combining compounds multiplies the variables in an experiment and makes results harder to read, so researchers plan these designs carefully and change one factor at a time

[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Qiu Y, Benet LZ, Burlingame AL

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