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However, they did not explore the underlying mechanism

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Long-term impacts It is common and understandable for family members to have many questions about the long-term effects of the brain injury on the injured persons ability to function in the future

More recently, it has been demonstrated that NSC-34 cells expressing TDP-43 mutants also exhibit shortened neurites, increased OS, and decreased HO1 level, and these effects can be reversed by the UPS inhibitor MG132, but not by the Nrf2 activator sulforaphane [255, 256], probably because MG132 induction of HO1 is Nrf2 independent

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Biochim Biophys Acta 1724:108118