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Individuals homozygous for 677TT may have approximately 30% of normal MTHFR enzyme activity, as described in the foundational work by Goyette et al

Wilcock, G

Normal dosage, good quality

Sidell 1997) Pupils are of normal size in a significant minority of poisoned patients (20% in one series)

For example, in a preclinical study, curcumin was found to reduce levels of heat shock protein 27 (HSP27) and P-glycoprotein (P-gp), causing an increase in the sensitivity of colorectal cancer cells to the chemotherapeutic drug 5-fluorouracil (5-FU), which led to enhanced cell death in 5-FU-resistant HCT-8 cancer cells (He et al

Sixty percent of affected children develop symptoms by the age of 1 year and 90% present by the age of 5 years