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To further validate the multivalent interactions of D-CuP, SPR analysis was performed to quantify its binding ability to p53 and HDAC7 in comparison with M-CuP

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It hits gene expression controls, including potential histone protein binding and regulation of specific DNA regions

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All data in Figures are included in this article and its Supplementary Information files

Structure of FOXO isoforms FOXO proteins have a structured winged-helix type of DNA binding domain (DBD), followed by a largely unstructured, flexible tail containing nuclear export sequences (NESs) and a transactivation domain (TAD)