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In addition, the increasing of oxidative and nitrosative stress in the heart during aging and the decreasing of hydrogen sulfide (H 2 S) concentration along with a decline of a constitutive synthesis of nitric oxide (NO) collectively lead to the dysfunction of mitochondrial mechanisms, in particular to the formation of a non-selective channelsthe mitochondrial permeability transition pores (mPTP) in the high-conductance mode, which is the cause of many pathological conditions (Strutynska et al., 2016

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10.3390/molecules28083386 16 HsuC.-L.WenY.-T.HsuT.-C.ChenC.-C.LeeL.-Y.ChenW.-P.et al (2023)

Consequently, we generated functionalized pSiNPs for the delivery of erucamide both in vivo and in cultured tissues