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Formation and fate of nephrotoxic and cytotoxic glutathione S-conjugates: cysteine conjugate -lyase pathway

As pointed out, further clinical studies of higher scientific quality analyzing long term application and clinical outcomes are needed to support evidence for the use of silymarin in different types of chronic liver disease

Finally, we highlight major limitations in the current evidencesuch as heterogeneous dosing regimens, the scarcity of long-term clinical data, and insufficient mechanistic validation under MASLD conditionsand propose directions for future translational research

J., Katoh, Y., Igarashi, K

Churchward-Venne TA 1 , Breen L, Di Donato DM, Hector AJ, Mitchell CJ, Moore DR, Stellingwerff T, Phillips SM

PMID: 143 LiYXiaDChenJZhangXWangHHuangLet al