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10.1016/j.bbcan.2016.12.002 7 BlaserH.DostertC.MakT

Impacts of clinicopathological factors on efficacy of trastuzumab deruxtecan in patients with HER2positive metastatic breast cancer

Pediatrics, 145 (1), Article e20193447

This study revealed a complex metabolic situation determined by insulin and palmitate in CACT-deficient cells, and has provided insight into the functional interactions between CACT, CPT1, malonyl-CoA, and acetyl-carnitine 59

In the author's observations, making treatment decisions contingent of the blood levels of co-enzyme Q10, carnitine and amitriptyline was very helpful in many cases, as children with sub-optimal clinical improvement always demonstrated a low level of at least one of the three agents, and increased dosing was associated with the resolution of episodes