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C9orf72 was also shown to be a Rab guanine exchange factor (GEF) involved in the modulation of Rab activity (Iyer et al., 2018), which regulates NOX2 recruitment to phagosomes in dendritic cells (Jancic et al., 2007)

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The NLRP3 and NLRP12 inflammasomes are activated by various stimuli and help express IL-1 and IL-18 in PC [34]