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In addition to these findings, recent work has shown that miRNAs in GC regulate key oncogenic pathways such as Wnt/-catenin, HMGA2/mTOR/P-gp, PI3K/AKT/c-Myc, VEGFR, and TGF-, contributing to tumor proliferation, metastasis, and chemoresistance [40]

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GSTs involved in flavonoid transport have been linked to membranes, including the endoplasmic reticulum (ER) and the vacuole (Zhao, 2015)

In subsequent validation experiments, the embedded tissues were sliced at a thickness of 8 m using a cryostat, and every 10th section was collected for HE staining and ovarian area measurement

However, exposure of human islets to prolonged hyperglycaemia suppresses PTBP1 expression and insulin biosynthesis, possibly due to the concomitant upregulation of microRNA (miR)-133a, which binds to the 3-UTR of PTBP1 mRNA [46]