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Comparison of two extraction systems

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Unfortunately, many of these tools still need large training data or further adjustments for detection improvement [28], while they are also able to detect only specific DNA methylation patterns (e.g

Rather, they often present concurrently, in varying severity, and are intertwined with and influence each other (Figure 1)

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These differentially methylated CpG-related genes are highly enriched in biological processes related to DPN progression, such as neurodevelopment, neuronal development and axon guidance, glycerophospholipid metabolism, and mitogen-activated protein kinase (MAPK) signaling