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Similarly, prenatal exposure of pregnant C57BL/6J mice to PQ (0.3 mg/Kg) or maneb (1 mg/Kg) altered the development of the nigrostriatal system and enhanced its vulnerability to neurotoxins later in life, which could contribute with the development of PD during aging (Barlow et al., Although there is no direct evidence linking early exposure to environmental pollutants and epigenetic changes with increased susceptibility to LOPD, there is a plausible association based on the following considerations: (1) epigenetic alterations have been observed in PD brains

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Expression of antioxidant enzymes by reverse transcription quantitative polymerase chain reaction (qRT-PCR) To quantify the expression of iNOS, SOD1, CAT, and GPx, BSC-40 cells were seeded in 6-well plates and infected with VACV (MOI 1) or with culture medium as a control (seven samples/group)

The coated specimens were observed and photographed with an SEM (HITACHI SU8100, Tokyo, Japan)