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To study the permeability of nanoparticles in vitro BBB models, which conform to the 3R principles with the minimalization the number of animal experiments, are widely used either in static [34] or in dynamic conditions by employing lab-on-a-chip systems [35]

Plant Physiol 143(3):11731188

Similarly, zinc-finger proteins, which bind zinc ions to stabilize their structures, have been targeted with metal-based compounds like aurothiomalate, which disrupt the zinc-cysteine interactions in the proteins active site, providing a novel approach to chemotherapy and against HIV (Medici et al., 2015)

Mollugin (5 mg/kg, 10 mg/kg per day) attenuated in vivo eosinophil infiltration, lung eosinophil peroxidase activity, and epithelial mucus secretion in lung tissues of ST-induced asthma murine models [66]

Biochimie 95(8):16291639 Tripathi D, Jena G (2010) Astaxanthin intervention ameliorates cyclophosphamide-induced oxidative stress, DNA damage and early hepatocarcinogenesis in rat: role of Nrf2, p53, p38 and phase-II enzymes