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As fibrosis progresses, tissue stiffening and local hypoxia further promote persistent epithelial injury and myofibroblast activation, creating a vicious cycle that drives disease progression [37]

Longevity signals (preclinical): Some long-term rodent studies describe lifespan-related effects framed as hypotheses, not proven benefits

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Patients might also notice tiny lines on the skin where the mites have burrowed