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Mechanism The mechanism of ferroptosis mainly includes the following three aspects: SLC7A11/GPX4 pathway (System Xc- pathway) : GPX4 utilizes a glutathione (GSH)-dependent catalytic mechanism to reduce peroxide bonds (-OO-) in lipid hydroperoxides to hydroxyl groups (-OH), thereby neutralizing their oxidative activity (Ursini and Maiorino 2020)