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The results showed that VRK2 knockdown could induce an increase of ROS and decline of cell viability and GSH following TBHP treatment, while these alterations could be partly reversed by ectopic SLC7A11 expression but not GCLC or GSS expression (Fig

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Cancer Cell 33 , 91107 (2018)

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Signal Transduction and Redox Signaling : Investigates S-glutathionylation and how it can change enzyme activity and transcriptional control

The organic layer was washed with brine and water, dried with anhydrous Na 2 SO 4 , filtered and concentrated under vacuum to afford crude product which was purified by chromatography on a silica gel column to give Sj001, yellow oil, 30 mg, yield 23%