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This means that DNA adducts, which are repaired and appear in the urine, can be used as surrogate biomarkers of DNA damage Citation[119,120]

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vii) first- and second-order asymmetric transformationsa technique whereby diastereomers from the racemate equilibrate to yield a preponderance in solution of the diastereomer from the desired enantiomer or where preferential crystallization of the diastereomer from the desired enantiomer perturbs the equilibrium such that eventually in principle all the material is converted to the crystalline diastereomer from the desired enantiomer

Acknowledgments We would like to thank Jiaying Yan for her contribution to section 5.2 during the revision of this paper