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Three previous studies that found an increase in uncoupling protein (UCP2) expression [26, 73] and protein [31] in LCLs derived from children with ASD, particularly the AD-A LCLs [31]

As such, leptin, like many immune system mediators, functions as signaling molecules of both the immune and metabolic systems and is considered the cornerstone signal that links these two systems, as through which they regulate and influence each other (158)

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The journal was initially contacted by the last author to report the unavailability of the raw data of the results presented by the article and thus the unreliability of the article results

Its mechanism of action involves inhibiting the activity of nicotinamide-nicotinamide dinucleotide transferase (NNMT), thereby increasing levels of nicotinamide adenine dinucleotide (NAD+), a key coenzyme involved in numerous cellular reactions

It can also result in confusion and personality changes