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FUT2 promotes colorectal cancer metastasis by reprogramming fatty acid metabolism via YAP/TAZ signaling and SREBP-1

But its not just about gut health

Over time, mitochondrial damage accumulates, impairing their efficiency and releasing DAMPs into the cellular environment, which further stimulates inflammatory signalling, creating a selfperpetuating loop of mitochondrial dysfunction and OS, ultimately impairing energydependent wound repair processes such as cell migration and matrix deposition [52]

10.1016/j.neuroscience.2008.08.035 205 TalpadeD

Ethics declarations Competing interests All authors are employees of The Institute of Cancer Research, which has a commercial interest in abiraterone acetate

The hope that this therapeutic approach would not have suffered by the phenomenon of resistance was based on the fact that was targeting normal vessels rather than tumour cells prone to mutation and subject to drug induced selection