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Gibson GE, Sheu KF, Blass JP, Baker A, Carlson KC, Harding B, et al

In addition, combined therapy targeting oxidative stress response also show enhancement of the sensitivity to glutaminase inhibition (60, 130)

Approaches such as intrathecal, intracerebroventricular, and intraparenchymal injections, as well as transient BBB disruption, have been employed to deliver drugs with limited CNS bioavailability (Ganger and Schindowski, 2018