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To evaluate whether AATF promotes NHEJ repair by inhibiting XRCC4 degradation, we expressed Flag-XRCC4 in AATF-KD GSCs

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The ACLD was defined as LSM 10 kPa and/or FIB-4 3.25 and/or ultrasound signs of cirrhosis

Genetical evidence from key studies confirms that eliminating GPX4 expression via genetic knockout in various cell types, or directly targeting its active site with small molecule inhibitors like RSL3, consistently and efficiently induces typical ferroptosis (Wang L

Environ Sci Pollut Res Int 31:1060910620

Speakman et al., 2016), which appears to be because a period of daily fasting is a critical part of the rodent DR effect ( E