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6H 2 O) were purchased from Shanghai Chemical Reagent Company (Shanghai, China)

Fourth, ZZ1 induced ternary complex formation slowly in biochemical assays when compared to ZZ1-SO 2 H (Extended Data Fig

Aside from antioxidant metabolism and regulation in response to elevated ROS, cells also recruit components of the DNA damage response (DDR) pathway to cope with the potential damaging effect of free radicals on DNA 29,43

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They boost glutathione levels

Kim AL, Zhu Y, Zhu H, Han L, Kopelovich L, Bickers DR, Athar M (2006) Resveratrol inhibits proliferation of human epidermoid carcinoma A431 cells by modulating MEK1 and AP-1 signalling pathways