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These interactions have been proposed as a mechanism through which the peptide may influence gene expression programs associated with cellular senescence (Vanyushin et al., Biochemistry (Moscow), 2014)

Boomsma F, van den Meiracker AH, Winkel S, Aanstoot HJ, Batstra MR, Man in t Veld AJ, et al

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Onaolapo OJ, Onaolapo AY, Olowe OA et al (2019) Melatonin and melatonergic influence on neuronal transcription factors: implications for the development of novel therapies for neurodegenerative disorders

Thats thanks to the nitric oxide boost, which improves blood flow, endurance and overall performance