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The basic principle underlying this method is that a marker substance will be distributed in the body fluid compartments according to its physical characteristics

Rather than flooding synapses with a single neurotransmitter, it modulates the balance between serotonin, dopamine, and norepinephrine, nudging each toward optimal levels rather than artificially elevating one at the expense of others

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Notably, the ephrin pathway, which regulates cell signaling, cellular morphology, stem cell niche maintenance, axon guidance, and energy metabolism was found to be upregulated in ME/CFS patients

In native biological models, complex structural injuries and chronic inflammatory states engage multiple, overlapping cellular networks