glutathione peroxidase enzyme mimetics New mimetics—Insights into antioxidant and cytotoxic activity Glutathione peroxidase-like functions of 1,2-diselenane-4,5-diol

The historically important question, which has been the subject of frequent discussions, is whether oxidative stress is the primary cause or secondary consequence of the disease

doi: 10.1016/S1470-2045(23)00444-8 35 LoMWangYZGoutPW

Crucially, we integrate the parallel and essential discourse on safety, highlighting how zebrafish models, especially transgenic lines, enable the real-time visualization and mechanistic interrogation of compound-induced hepatotoxicity

the yeast strain has a mutation that reduces the ability of the strain to synthesise one or more proteins, metabolites and/or essential growth factors which may optionally be included in the culture medium in limiting amounts, depending on the capacity of the yeast strain to synthesise said proteins, metabolites and/or essential growth factors

Tax1 binding protein 1 (TAX1BP1), functioning as an autophagic receptor for GPX4, facilitates this degradation, leading to enhanced lipid peroxidation and subsequent ferroptosis [57]

M2 macrophages possess a weak antigen-presenting ability, and secrete anti-inflammatory cytokines such as IL-10 or TGF-, and down-regulate the immune response [88,89,90].Tumor-associated macrophages (TAMs) have been shown to be functionally plastic as a special type of macrophage, which are often described as M2-like population, but there is also evidence for the existence of M1-like population [91,92,93].In fact, in the early phase of tumor establishment, TAMs display an inflammatory phenotype, but an immunosuppressive phenotype is present at the later stages of tumor progression [94]