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In addition to non-enzyme-dependent lipid peroxidation, macrophages can produce HNE via COX2

Although it has long been speculated that BAT degenerates in healthy adults, metabolically active BAT was rediscovered in healthy adults via advanced imaging techniques, substantiating the notion that BAT might serve as a modifiable target for the prevention and treatment of obesity and type 2 diabetes [8-11]

There are majors risk associated with ERCP including cholangitis and pancreatitis

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[6] Devathasan G, Teo WL, Mylvaganam A

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